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Abstract #4062

MR Elastography of Renal Transplants: Correlating Stiffness with Interstitial Fibrosis and Tubular Atrophy

Sudhakar Kundapur Venkatesh1, Gang Wang2, Thomas Paulraj Thamboo3, Eugene Liu2, Edwin PY Siew2, Vathsala Anantaram4

1Diagnostic Imaging , National University Health System, Singapore, Singapore; 2Diagnostic Imaging, National University Health System, Singapore, Singapore; 3Pathology, National University Health System, Singapore, Singapore; 4Nephrology, National University Health System, Singapore, Singapore

Chronic allograft nephropathy is a common cause of renal transplant failure and characterized by interstitial fibrosis and tubular atrophy-IFTA. We investigated transplant stiffness and correlated with histological grade of IFTA. Our study did not show any significant correlation with stiffness and grade of IFTA suggesting that other changes including tubular atrophy, glomerulosclerosis and arteriolar hyalinosis and altered perfusion may contribute significantly to stiffness. Our study did show significant differences between normal group and those with IFTA. More work is needed for determining the utility of renal transplant stiffness measurement with MRE and its relation to the histological changes.

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Keywords

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