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Abstract #4048

Feasibility Study of Assessing Progression of Chronic Liver Disease with MR Elastography in an in vivo Animal Model

Meng Yin1, Kevin J. Glaser1, Jason L. Bakeberg2, Christopher J. Ward2, Peter C. Harris2, Richard L. Ehman1

1Radiology, Mayo Clinic, Rochester, MN, United States; 2Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States

A feasibility study was performed for measuring hepatic shear stiffness in small animals to identify whether a selected animal model merits further study to see if hepatic stiffness correlates with hepatic inflammation and fibrosis progression. The results of this preliminary study demonstrated that increased liver stiffness is an early marker of disease progress in a Pkhd1 mouse model. If these results can be further confirmed with more sophisticated mechanical models to separate fluid-related inflammation and matrix-related fibrosis effects, MRE may provide means to distinguish hepatic inflammation before the onset of hepatic fibrosis.

Keywords

acute agreed animal animals anisotropic assessing assuming attenuation biological biopsy birdcage blanket body born caused chronic clinic coil collagen complex complications control correlate cyst deposition derived detection develop developed development differentiation direct discriminate disease diseased distinguish dynamic early encoding errors evaluate examined experience extents feasibility female fibrosis flanked fluid formation general generate global grade grading hepatic hepatitis histology homogeneous hypertension identify illustrated important in vivo indicators infiltrate inflammation inflammatory interstitial invasive investigations kidney known least lifespan linked liver male many marker materials matrix mayo mechanical mice mild model models mouse mutations nonlinear onset part patients persist peter pilot poorly potential practicality problems produced progresses progression progressive properties published quickly radiology recessive related reported respectively response risks sampling selected separate shear sided significance significantly silicon since slices soft stiffness studies system tend terminated theoretical therapy tissue tissues torsional trans type usually vary varying vibration vibrations viscoelastic ward wave waves week whole widely wild younger