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Abstract #4046

Voxel-Wise Reproducibility of Magnetic Resonance Rheology of the Liver at 3T MRI

Anneloes E. Bohte1, Aart J. Nederveen1, Paul F.C. Groot1, Annikki de Niet2, Peter L.M. Jansen2, Ralph Sinkus3, Jaap Stoker1

1Radiology, Academic Medical Center, Amsterdam, Netherlands; 2Gastroenterology, Academic Medical Center, Amsterdam, Netherlands; 3Radiology, Hpital Beaujon, Paris, France

Liver fibrosis can be detected by means of Magnetic Resonance Rheology (MRR, also known as MR elastography). It has the potential to replace liver biopsy in patients with chronic liver disease. If this measurement becomes part of the clinical routine, one needs to know which changes in liver elasticity and viscosity over time can be accurately measured. In this study we define a threshold for detecting a significant change in both liver elasticity and viscosity in repeated MRR measurements in a group of 27 subjects containing both healthy volunteers and patients with viral hepatitis B/C.

Keywords

academic acceptable acquisition adapted aimed analyses anatomical applicability attributed avoiding axial better biopsy bland bottom boundaries boundary calculating chest chronic cirrhosis clinical coefficients cohort coil comparable copied correcting decrease decreased decreasing define defined detecting detection determined disease displacement distributed driven elasticity equals especially evaluation examined expected experimental fibrosis filter full function generated grades hardware healthy hepatitis heterogeneously horizontally important increasing index indicate influence influencing instead known lesions liver livers location longitudinal lowest manually maps marker matrix medical minor monitoring noise often outlining paired pairs participant participants patient patients pattern physiological physiology piston placed planar position potential precision predicts previous progression propagating proven radiology reflects registered registration regression related relation repeatability repeated repositioning reproducibility reproducible resolution rheology rigid role scanned serve session significantly slightly software spatial spatially step studies subsequently system table technical threshold throughout today trade transmitting twice unrelated variations vector vessels viral viscoelastic viscosity volunteers waves weeks width wise yielded