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Abstract #4010

Dynamic Whole-Liver Imaging Using a Spiral Acquisition Technique: Feasibility and Initial Results in Assessment of Liver Fibrosis

Krishna Juluru1, Jonathan P. Dyke1, Pascal Spincemaille1, Andrew H. Talal2, Rhonda Yantiss3

1Radiology, Weill Cornell Medical College, New York, NY, United States; 2Medicine, Weill Cornell Medical College, New York, NY, United States; 3Pathology, Weill Cornell Medical College, New York, NY, United States

The purpose of this study was to prospectively assess the feasibility of dynamic whole liver imaging using a spiral acquisition technique for the purpose of evaluation of liver fibrosis. The spiral technique allows whole liver imaging with high temporal resolution, while maintaining spatial resolution, and permitting sliding window reconstruction. Enhancement curves demonstrate differences in perfusion between subjects who are normal and who have biopsy-proven liver fibrosis.

Keywords

ability achieved acquisition acquisitions advanced agent allows appearance assess assessment assisted bandwidth biopsy boulder breath cause characterize chosen chronic cirrhosis cirrhotic clinical college combined compartment computer concordance considered constant contains contrast curves death degree delayed despite diagnosis dimensional disease diseased documented dynamic either enable enhanced enhancement entire errors every exaggerated exchange excretion experience exploration extracellular failure feasibility fibrosis fits five gain golden grade greater healing healthy hepatitis hold hypothesize immediately increasing increasingly initial injection intensity journal leading leaf leaves limited liver maintaining makes matrix medical minute model morphologic negates noise observe ongoing organ parallel partial pascal patients perfusion plateau populations port post potentially problems process processed progress progression prospectively proven radiologist radiology readout receive reconstructed reconstruction recruited related require resolution risk sampling saturation selective short significantly slice sliding software spectrally spiral starting strong subject subjects sufficient temporal tomography transmit unique update uptake utilizing various view volumes whole window worthy wound written