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Abstract #3997

Quantitative Multi-Breath Fractional Ventilation Imaging in Voluntarily Breathing Humans

Kiarash Emami1, Hooman Hamedani1, Biao Han1, Yinan Xu1, Stephen J. Kadlecek1, Masaru Ishii2, Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

The feasibility of performing multi-breath fractional ventilation hyperpolarized gas MRI in human subjects are demonstrated. This methodology is the first to report a quantitative measure of respiratory gas distribution and replacement in human lungs. The detailed mechanisms of gas transport in lungs with heterogeneous ventilation defects require further investigation to explain the reflections on fractional ventilation values before proper interpretation can be made. Nevertheless fractional ventilation can now be evaluated as a quantitative regional marker to investigate heterogeneous obstructive lung diseases.

Keywords

abstract accelerated administered administration airways albeit allowed among animals artifacts artificially basis breath breathing breaths bronchi chest coil comparable complicated conditions consciously constant constants continuous contrary coronal defects delivery density described detailed developed device diagnosis directly diseases distribution drastically eliminated enable enabled errors especially evaluated evaluations exhibit extension fact fairly feasibility field finds five fractional good head healthy heterogeneous human humans identical important indicated indicating interpretation investigate judged last least likely lung lungs made maps marker mechanically methodology mixing mixture monitoring mostly nearly neck noninvasive observation obstruction obstructive overall overlaid oxygen pack passive patient poorly prepared prescribed progression proper proportionally protocol pulmonary qualitatively quantitative queued reactive recursive reflections regional remain repeatability report reported require requirement resolution respiratory response serial series several shunt slices smoker sonata spacing spatial spin stage studies subject subjects subsequent suspected synchronized systematic thorax titrated trachea translation transport underwent uniform unusually utilized ventilated ventilation visible volume volumes voluntarily