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Abstract #3995

Parallel Accelerated Imaging of Alveolar Partial Pressure of Oxygen

Stephen J. Kadlecek1, Yinan Xu1, Kiarash Emami1, Yi Xin1, Puttisarn Mongkolwisetwara1, Hooman Hamedani1, Harrison McAdams2, Masaru Ishii3, Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Biological Basis of Behavior Program, University of Pennsylvania, Philadelphia, PA, United States; 3Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

An improved method to image PAO2 maps in human lungs is proposed using parallel accelerated HP 3He MRI. Using computational models and phantoms it is shown that when used effectively, accelerated undersampled imaging can lead to a more accurate measure of oxygen tension in the lungs. Technique feasibility and advantage is demonstrated in a healthy human subject. The improvement in PAO2 accuracy is linked to the more efficient use of the finite polarization of HP gas and by increased weighting of the O2-induced contrast versus RF-induced signal decay. Potential confounding factors, e.g., image artifacts or blurring due to accelerated reconstruction, are not observed in this study.

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Keywords

accelerated acceleration acceptable accounting accuracy achieve acquisition acquisitions additional adversely affect allowed alveolar among appear array artifacts assumed available basis best better blue blurring breath coil coils computational conditions confirm consisted consistency constraint contrast decay delay depicts deviation diagnosis diffusion directly distribution earlier easier effective error especially examination example experiment feasibility features fidelity five flow frequency full fully gradient greater ground hand healthy highlighted histogram hold human important induced introduced investigate johns known long lung magnetization makes mapping maps mechanisms minimizing minute mixture models modes neck nominal numerical overall oxygen parallel partial particularly parts performance phantom posterior potential precision presence pressure process reconstructed reconstruction reconstructions reduced reduction regional relates reliable remains repeated representative saddle sampled sampling scheme schemes shaped simulation slice space spatial studies subject subjects suggest suggesting suggestive superiority surgery system temporal thereby timing tolerable transmit trends truth tuned uncertainty understanding underwent utilized variation various warrants wide widest width yields