Meeting Banner
Abstract #3975

Accurate T1 Mapping in Rodent Lungs Using Ultrashort Echo-Time MRI

Magdalena Zurek1, Daniel Alamidi1, Edvin Johansson1, Frank Risse1, Lars E. Olsson1

1Personalised Healthcare and Biomarkers, Imaging, AstraZeneca R&D, Mlndal, Sweden

A robust method for accurate assessment of T1 in rodent lungs was implemented. The sequence (segmented 2D-IR with ultrashort echo-time (UTE) and radial k-space sampling) was validated via simulations, and sequence parameters were optimized in a phantom study. The presented technique enables the T1 of pulmonary structures to be mapped with a high spatial resolution. The protocol has the potential to assess lung properties relevant in various animal models of pulmonary disorders.

Keywords

account accuracy accurate achieve achieved acknowledgments acquisition address agreement animal animals applied approved artifacts assess assessed assessment back bias bland board breathing carried confirmed constant containing correspondingly corresponds cylindrical depletion determine diagnostic diseases disorders doped dotted efficiency enables enhanced equal equations especially estimation ethics excitations fitting frank freely function furthermore good hampered highest illustrated implemented in vivo increasing instance intensity intra introducing inversion issues length local lung lungs many mapped mapping matrix maximizes measured models motion muscle needed noted observation optimal optimized optimum oxygen phantom phantoms pixel pixels plot potential prediction previously properties proposed protocol pulmonary pulse pulses quantitative radial rare rats reconstruction recovery reduce regional relevant repeated repetition reported represent resolution respiratory review robust rodent sample sampling scanner scheme segment segmented segments short simulate simulations slice spatial steps structures supported table taking temporal theoretical tissue train typical ultrashort validated validation various verify vials viewed yields