Meeting Banner
Abstract #3971

Quantification of the Effects of Alveolar Surface Tension Modulation by Magnetic Resonance Elastography (MRE).

Kiaran P. McGee1, Rolf D. Hubmayr2, Yogesh K. Mariappan1, Zhonghao Bao3, David L. Levin1, Rickey E. Carter4, Richard L. Ehman1

1Radiology, Mayo Clinic & Foundation, Rochester, Mn, United States; 2Pulmonary and Critical Care Medicine, Mayo Clinic & Foundation, Rochester, Mn, United States; 3Information Technology, Mayo Clinic, Rochester, Mn, United States; 4Health Sciences Research, Mayo Clinic, Rochester, Mn, United States

Pulmonary surfactant is lipoprotein complex responsible for decreasing surface tension at the alveolar air-fluid interface, is a known moderator of lung elastic recoil and a major contributor to lung stiffness. While surfactant can be assayed by bronchiolar lavage its spatial distribution and effects on lung stiffness cannot be directly quantified. We present first data demonstrating that magnetic resonance elastography (MRE) can quantify both global and regional changes in lung elastic recoil caused by loss of surfactant in a flooded lung. Regional increases in MRE-based lung stiffness with inflation pressure suggest that MRE can also predict areas of active recruitment.

Abstract PDF E-Poster Video

Keywords

absence active additional adult affected airway almost alteration alveolar anesthesia animal arrow assessment bloc blue bronchiolar capable care clinic commonly comparing compound conditions content corrected critical decreases deep deflated degassed density derived described doped echoes edema either elastic equal excision exhibit exhibits expression flooded flooding fluid forces foundation frequency full fully function gadolinium global grams greater heterogeneity highly hill host hypothesis identify immediately in vivo individual inflated inflation influences infrequently instead interface invasive labs latter linear liquid local loss lung lungs magnitude maneuvers maps mass materials mayo measured measures mechanical minute minutes modulation modulus move normalization novel partial partially pattern physical pink plugs post preparation press pressure pressures prior process protocols pulmonary quantification quantify quantifying readings recoil recruitment regional relatively removal repeated reported resolve resolving respiration responsible sacrificed scales science sciences sets shear situ slice slices software spatially statistically stiffness suggest suggesting surface surfactant table technology tension tissues undergo undergoing ventilator volume yellow