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Abstract #3960

Assessment of Pulmonary Perfusion Reserve with Adenosine Using Quantitative MRI Lung Perfusion

Jie Jane Cao1, 2, Yi Wang1, 3, Kathy Mcgrath1, Nora Ngai1, Joshua cheng1, Philip Marcus4

1Research, St Francis Hospital, Roslyn, NY New York, United States; 2Cardiology, State University of New York at Stony Brook, Stony Brook, NY New York, United States; 3Bioengineer, State University of New York at Stony Brook, Stony Brook, NY New York, United States; 4Medicine, St Francis Hospital, Roslyn, NY New York, United States

We investigated the lung perfusion response to adenosine challenge using lung perfusion quantitation by MRI in 26 volunteers. The absolute lung perfusion was increased by about 2 folds on average during adenosine infusion. Perfusion augmentation was achieved in all lung fields. Reduced lung perfusion was associated with impaired pulmonary function test at rest and during stress. Our findings suggest that quantitative assessment of pulmonary perfusion reserve is feasible using lung perfusion quantitation by MRI.

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Keywords

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