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Abstract #3950

High Spatio-Temporal Resolution Retrospectively Triggered CINE Imaging for Measuring Diastolic Function in Mice

Bram F. Coolen1, Desiree Abdurrachim1, Abdallah GA Motaal1, Klaas Nicolay1, Gustav J. Strijkers1, Jeanine J. Prompers1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

This study presents the use of retrospectively triggered CINE MRI for high spatio-temporal resolution diastolic function measurements in mice. A temporal resolution < 2 ms could be reached allowing accurate determination of the E and A diastolic filling rates. Using this technique, subtle reductions in diastolic function were observed in diabetic db/db mice compared to non-diabetic db/+ mice.

Keywords

accurate acquisition acquisitions addition allows altered application applied artifacts attributed automatic bars beat best biomedical blood built capture cardiac characterized cine clear clearly clinical compromising cont contraction contrast contributions created creating curves custom cycle definition delays denoted derivative detection determination determined determines diabetic diastolic distortions dysfunction early echoes engineering especially eventually example experiment findings flow frames function gave gives gradient hardware healthy heart home immediately improvement independent individual infinite initial interleaving interpolation investigate known late marks match measured measures measuring mice models motion mouse navigator note onset open optimize oscillations part peak performance post prevent prospective quality rather reach reconstructed reductions related relies repetitions resolution retrospective retrospectively running scanner segment segmenting semi separate sets sharing short significantly slice slightly smooth smoothed smoothing software space spatial start statistics steady steps still strongly studies subsequently subtle suffered sufficiently temporal tended theory trigger triggered triggering true typically variations varied various ventricle ventricular volume weeks