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Abstract #3837

Highly-Accelerated, Single Breath-Hold 3D Cine B-SSFP MRI with a Combination of Compressed Sensing and Parallel Imaging

Daniel Kim1, Alexis Harrison2, Wilson King3, Li Feng4, Elwin Bassett5, Christopher J. McGann2, Nassir F. Marrouche2, Ricardo Otazo6

1Radiology, University of Utah, Salt Lake City, UT, United States; 2Internal Medicine, University of Utah; 3Division of Pediatric Cardiology, University of Utah; 4Sackler Institute of Graduate Biomedical Sciences, New York University; 5Physics, University of Utah; 6Radiology, New York University

Breath-hold cine b-SSFP MRI is the gold standard for imaging myocardial function. The need for multiple breath-holds, however, increases the examination time and likelihood for patient exhaustion from repeated breath-holds. We sought to develop a single breath-hold 3D b-SSFP cine MRI pulse sequence with 12-fold acceleration using a standard coil array, by employing a combination of compressed sensing and parallel imaging that exploits joint sparsity among all coil datasets, and compare its performance against multi-slice 2D b-SSFP cine MRI for LV function quantification. All four global function measurements (EDV,ESV,SV,EF) were in good agreement, with coefficient of variation ranging from 6-12%.

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Keywords

accelerated acceleration accurate achieve acquisitions adaptive adult agreement aliasing among analyses approximately array arrays artifacts avoid bland blinded blood breath cardiac cardiologist cardiology cine coefficient coil combination comparable compressed considered contiguous contours cover cycle decreasing difficult discarded displays distance division dummy ejection electrocardiogram element eliminate employ employing entire equipped evaluation examination excellent except exploits feasible fold former free function gaps global healthy held highly hold holds included incoherent independently joint king lake latter likelihood limit magnetization matrix minimized myocardium need nevertheless parallel partition pattern pediatric performance physics pixel pooled produced proposed prospective protocol protocols pulse quality quantification radiology randomized ranging readers reconstructed reconstruction reformatting relatively relevant repeated representative requires resolution respectively retrospectively sampled sampling sciences segmentation sense sensing sensitivity sets several slice slices software sought sparse sparsity specifically sponsor stacks steady stroke suitable system systolic table temporal thick transform transforms triggered triggering trio typically variation views volume volunteer volunteers whereas white