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Abstract #3818

ADC Mapping for Carotid Plaque Characterisation

Victoria Young1, Andrew J. Patterson2, Umar Sadat3, Andrew N. Priest2, Robert van de Geest4, Martin J. Graves1, 2, Jonathan H. Gillard1

1Radiology, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 2Medical Physics and Engineering, Addenbrooke's Hopsital, Cambridge, United Kingdom; 3Vascular Surgery, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 4Radiology, Leiden University Medical Center, Leiden, Netherlands

High resolution MRI is an option in the assessment of carotid atherosclerosis but there are limitations of unenhanced imaging in complex plaque and evaluation is subjective. DWI through ADC mapping has been applied both in vivo and ex vivo to quantitatively differentiate lipid core and fibrous tissue. This study evaluated a larger patient population to demonstate this separation could still be seen in a broad range of stenoses and to show plaque thrombus also demonstrated a different ADC value which varied with thrombus age. This evidence increases the value of ADC mappingin demonstrating vulnerable plaque characteristics.

Keywords

ability advantages aging aids another anteriorly apparent applied applying array arterial artery atherosclerosis automated automatically background bands benefit bilateral broad broader calcification cardiac carotid category channel circulation classification classified coefficient coil component components computed condition confirmation considered containing contrast core define degree delineated delineation deviation diffusion diseased distinguish double engineering events examine excluded expanded expected fast feature fibrous finding formed fresh gating generated gradients graves histological hospital identified identify illustrated important in vivo include individual inferiorly inversion kingdom lack larger limitation lipid locations lumen major males mapping maps martin matrix median medical mixed model morphology part patient patients physics planar plaque population posteriorly previous previously priest providing published quantitative radiology recent recovery recruited relate reported represent resolution risk role ruptured saturation section semi shot significantly slice spatial specimens spin stir stroke studies subsequent suggested suitable superiorly suppressed symptomatic symptomatology table thick thrombus tissue transferred types ultrasound variable variation vascular wall whole wrapping young