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Abstract #3782

Toward Assessment of Iron Overload Diseases at 7.0 T: Myocardial T2* Mapping to Derive Global and Segmental T2* Norm Values for Healthy Subjects at 7.0 T

Fabian Hezel1, Antonella Meloni2, Jeanette Schulz-Menger1, 3, Petra Keilberg2, Peter Kellman4, Massimo Lombardi2, Thoralf Niendorf1, 3

1Berlin Ultrahigh Field Facility, MDC Berlin, Berlin, Germany; 2Cardiovascular MR Unit, Fondazione G. Monasterio CNR-Regione Toscana and Institute of Clinical Physiology, Pisa, Italy; 3Experimental and Clinical Research Center (ECRC), Charit Campus Buch, Humboldt-University, Berlin, Germany; 4Laboratory of Cardiac Energetics, National Institutes of Health/NHLBI, Bethesda, MD, United States

Myocardial T2* mapping is of proven clinical value for the detection of iron overload. Ultrahigh field (>7T) offer a gain in susceptibility sensitivity, however T2* relaxation rates of healthy myocardium obtained at 1.5T and 3.0T need to be revised. This study aims to determine T2* relaxation times for normal myocardium (global and segmental) in healthy subjects with the ultimate goal to establish a lower limit of normal T2* at 7.0T.

Keywords

access achievable adjusted affected always anterior anticipate apical appealing array artifacts assessment axis basal bears benchmarked blinded blood breath capabilities cardiac cardiovascular chamber characterization clinical coefficient coil combination comprising constraints content contrast correlation derived detected determined diastole dictated diseases dominate driving efforts element establish evaluate evaluation examination extend feasible field fields focuses force gating global healthy heart held includes indicates induced inherent inhomogeneities institutes interclass interface invasive involved iron laboratory lateral lead limit located long lung macroscopic make males mapping maps matrix microscopic middle myocardial myocardium nominal norm offset operator overall overload parametric peter physiology pilot posterior preserve prolongation pronounced prospective pursue quality quantification ranging rather recognized reduce reducing related reported residual revised saturation segment segmental segmented segments selective septum severe shim shimming short since slice software strength strengths studies subjects susceptibility system systole systolic tolerated toward towards ultimate ultrahigh uniform vein ventricle ventricular view views volume wall whole whose written