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Abstract #3763

White Matter Microstructure in a Healthy Population Aged 50-65; Automated Tractography Method and TBSS.

Live Eikenes1, Eelke Visser2, Asta Hberg1

1Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway; 2Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, Netherlands

White matter (WM) microstructure were studied at the population level in a cohort of 1006 healthy participants (50-65 years) using a new automated tractography method and tract-based spatial statistics (TBSS). The tractography results demonstrated that mean fractional anisotropy (FA) and volume of corpus callosum was higher in males compared to females. TBSS showed decreased FA in large areas of the white matter with increasing age, and higher FA in females than males in the occipital lobe, and higher FA in males than females in the deep central WM structures and in association tracts in the frontal and temporal lobes.

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Keywords

acquisition aged aging ample analyze anisotropy association atrophy automated automatic available balanced berg blue brain carried central clinical clustering cognition cognitive cohort collinear consistent core corpus corrected decreased deep derive examined explain exploit explore extent female females formation fractional frontal future general health healthy human hunt identification increasing individual individuals inferior institute integrity investigate lesion live lobe lobes longitudinal loss males mass materials matrix measures nonparametric northern occipital participants participating partition pathology permutation population populations preliminary project quantitative questionnaire random relationship remained removed sample scanner science segment segmentation shot significantly skeleton slice spatial statistics streamlines structural structures studies subjects subpopulation successful superior survey technology temporal tract tracts unmapped visualize volume white years