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Abstract #3760

Quantitative 7T Detection of Gadoteridol in the Ventricles of the Aging Human Brain

Valerie C. Anderson1, David P. Lenar1, Phillip C. Berryhill1, Joseph F. Quinn2, Jeffrey A. Kaye2, William D. Rooney3

1Neurological Surgery, Oregon Health & Science University, Portland, OR, United States; 2Neurology, Oregon Health & Science University, Portland, OR, United States; 3Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States

1H2O R1 values were determined in the superior lateral ventricles of 34 healthy older subjects (68 6 yrs; 13 M, 21 F) at 7T before and 3 times (within 50 min) after gadoteridol (CR) administration. Fractional CSF volume was determined by segmentation of structural T1-w images. A significant inverse correlation of pre-CR R1 values with ventricular volume was observed. R1 values increased at each time point after injection of CR, confirming that administration of CR increases R1 in the ventricles of the human brain. R1 values after CR administration were increased significantly more in women than men.

Keywords

abnormalities accounting administration advanced aging alterations analyses averaging axial barrier bilateral binary blood bottom brain cells choroid class clearance coil collected college concentrations constants constraint context contrast correlated course dataset decrease decreased delays dependent detection dilatation disturbances dynamics early elderly enrolled ensured equation erosion evaluation excluded exhibit expansion fast features female females finding fits fluid flux form free full function gadolinium gender grant hallmark head health healthy human humans injection inspection instrument inversely inversion investigate known lancet lateral leading leakage library likely linear lining little long macromolecular males maps mask measured measures minimal molecular necessary neurology opportunity outliers overall parametric partial partnership permeability plexus post potentially powerful prepared prior probe protein proton pulses quantitative reagent receive recovery reflect regression relatively repeated representative resolution science significantly since slice smith software source spaces statistical strongly structural subject subjects substantiate suggests superior support temporal tool transmit variable varies ventricles ventricular visual volume water zone