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Abstract #3743

Aging Effects on Cerebrovascular Response to Breath Holdings as Measured by Blood Oxygenation-Level Dependent MRI

Yuan-Yu Hsu1, 2, Ho-Ling Liu3, Ling-Yi Huang1, 3, Kun-Eng Lim1, 2

1Radiology, Buddhist Tzu Chi General Hospital-Taipei Branch, Xindien, Taipei, Taiwan; 2School of Medicine, Tzu Chi University, Hualien, Taiwan; 3Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan

This study aimed to evaluate the regional differences in cerebrovascular response to hypercapnia challenges between young and elderly adults. Twenty young (F/M = 10/10, mean age = 28.2 y/o) and twenty elderly (F/M = 12/8, mean age = 64.4 y/o) adults were studied by 3-T BOLD MRI during repeated 15-second breath-holdings. Significant breath-hold regulated BOLD signal increases were identified in gray matters. Compared to the young group, the elderly had a 50% decrease in the activation volume. There were significantly less BOLD signal increase in amygdala and dentate nucleus in elderly than in young adults (P < 0.001).

Keywords

activation adults affect aging aimed alterations analyzed applied arrows arterial assumption blood blue bold brain brains branch breath breathing bright cardiovascular causes cerebral challenges clinical comparable comparing comprised considered constant consumption corrected correction cortical curve cycles delay deliver dependent detected determined diabetes disease disorder dynamic elderly elevated emission evaluate evaluating except expected extent extracted findings fitting flow fractional function functional furthermore general gradient gray green healthy heterogeneity hold holding holdings hospital hypertension identified identify induces inhalation kernel leads linear ling little major matrix measured medical medicine minute model motion much natural neurological normalization nucleus ones otherwise oxygen oxygenation paradigm period periodic positron preparation preprocessing previous problems program radiological radiology recently recruited regional regulated related repeated reserve resolution respectively response sample scanner scattered school sciences short shot significantly slice smaller smoothing spatial stage stress studies subject subjects surface tension threshold tomography twenty ultrastructure uncorrected vascular volumes white whole year young younger yuan