Meeting Banner
Abstract #3733

Quantitative Evaluation of Cortico-Callosal Wallerian Degeneration with Diffusion Tensor Imaging in Moderate Traumatic Brain Injury

Richa Trivedi1, Maria M. D'souza1, Hemal Grover1, Ajay Chaudhary2, Pawan Kumar1, Prabhjot Kaur1, Rajendra P. Tripathi1, Subash Khushu1

1Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2Neurosurgery, Dr. Ram Manohar Lohia Hospital, Delhi, India

Given the widespread interhemispheric connections that course through the corpus callosum (CC), callosal pathway disruptions can have a profound impact on cognitive functioning. Serial quantitative diffusion tensor tractography was performed in five patients with moderate unifrontal lobe TBI. On follow-up study, significantly reduced callosal FA values were observed on moving from controls to injured hemisphere through contra-lateral normal appearing hemisphere in the subregions of anterior CC. We conclude that DTT based quantification in frontal lobe injury may be useful for wide spread assessment of DAI in callosal fibers and help in prognosticating disease outcome.

Keywords

affect anterior appearing assessment assignment automated body brain bundles cognitive connections continued continuous contra control controls corpus correspond corresponds course damage days death decrease decreased degeneration denotes described detail developed developmental diffuse diffusion diffusivity disruption disruptions divided division documented dual either elsewhere evaluation expressed extra fact females fiber fibers five focal fractional frequent frontal functions generated gives graph grover head healthy help hemisphere history house hypothesized impact included inferior injured injury institutional inversion known lancet lateral lobe loss major males many matched materials median mediating medicine moderate months neurological nuclear often parietal pathologies pathway patient patients phys presumably principle processing prognosticating progressive protocol quantification quantify quantitative recent recruited reduced reflect related reported restricting rostrum sample sampling scale scanner sciences sensitivity seven severe shot significance significantly slices software space spread static statistical structures student studies subregions suggesting suggests superior tensor tract trajectory traumatic trend underwent useful usually utility white wide widespread years