Meeting Banner
Abstract #3717

Abnormal Anterior Corpus Callosum White Matter Integrity in Heavy Smokers Revealed by Tract-Based Spatial Statistics

Fuchun Lin1, Guangyao Wu2, Shiqi Yang2, Haopeng Peng2, Prasanna Ghimire2, Ling Zhu2, Guobing Liu2, Hao Lei1

1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China; 2Department of Magnetic Resonance Imaging, Zhongnan Hospital, Wuhan University, Wuhan, China

Tract-based spatial statistics was used to investigate white matter integrity in heavy smokers. Compared to healthy non-smokers, smokers show abnormalities in the left anterior corpus callosum connecting the bilateral orbifrontal and prefrontal cortices. The decreased FA in this region was reflected by decreased axial diffusivity and increased radial diffusivity, which is probably caused by axonal loss and disrupted integrity of myelin. Moreover, in smokers, radial diffusivity in the left anterior corpus callosum was positively correlated with the duration of smoking. Our findings suggested that longer exposure to cigarette smoking is associated with decreased microstructural integrity of the left anterior corpus callosum in smokers.

Abstract PDF E-Poster Video

Keywords

abnormal academy acquisition addiction addition affected aligned anisotropy anterior applied assessed atomic axial brain china chronic cigarette clinical cluster collinear combined community controlled corpus corrected correlation corresponds cortices create currently damages decreased deficits dependence determine diagonalized diffusion diffusivity diseases disorders disrupted disruption distributions duration edition education eigenvalues encoding evidences examine females findings foundation fractional frontal functional gender generate gradient green heavy hemisphere history identify impact impairments importantly indicating innovation institute integrity interview investigate knowledge known laboratory little longer manual maps mathematics matrix measures medical medications metabolism molecular natural network nicotine nonparametric nonsmokers normalized objective onset people permutation physics positive processed program projected psychiatric psychiatry qualified questionnaire radial recent recruited reduced reflect reflected registered relationship republic revealed sciences score seven severity significantly skeleton slice smith smokers smoking song space spatial statistical statistics step structure structured studies subjects suggest supported taking tensor thirty threshold thresholded tract trio whether white wise yang years zero