Meeting Banner
Abstract #3712

Microscopic Damage to the Left Hemisphere Contributes in Determining Neglect in Patients with a Right Focal Lesion

Chiara Mastropasqua1, 2, Marco Bozzali1, Mara Cercignani, 13, Barbara Basile1, Sonia Bonn4, Giacomo Koch4, 5

1Neuroimaging laboratory, Santa Lucia Foundation IRCCS, Rome, Italy; 2Neuroscience, Trieste University, Trieste, Italy; 3Brighton & Sussex Medical School,Clinical Imaging Sciences Centre, University of Sussex, Brighton, United Kingdom; 4Laboratory of Clinical and Behavioural Neurology, Santa Lucia Foundation IRCCS, Rome, Italy; 5Stroke Unit, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy

Using tract-based spatial statistics (TBSS), we investigated the contribution of left hemisphere (LH) microstructural white matter (WM) changes in accounting for the presence and severity of hemispatial neglect in patients suffering from right-side stroke. TBSS analysis revealed a diffuse reduction of FA in most WM tracts of the LH, and a an association between neuropsychological measures of neglect severity and FA values in the region of the CC connecting the two parietal cortices. This study supports, on a microstructural basis, the theory that hemispatial neglect originates, by disconnection mechanism, from an unbalance of interhemispheric interaction between the two parietal cortices.

Abstract PDF E-Poster Video

Keywords

abnormality absence accepted account accounting anisotropy assess assessed association assumption asymmetry automated boundary brain clinical cluster combination connection contouring contribute controls conversely corpus corrected correlation cortices critical damage degeneration despite determining diffuse diffusion disconnection driven dual edited examined exclude extension fifth flair flirt foundation fractional free functional handed healthy hemisphere hemispheric human humans hypothesis ignored inattention indeed index intact integrity inter interactions investigate involvement kingdom laboratory lesion lesions likewise located macroscopic manifestations mapping matched mechanism medical micro microscopic might neglect neurology next none nonparametric overlap parietal part patient patients pattern permutation pipeline portion potential predominant preferentially preliminarily presence primer produce projections quantify rather recently recruited reduction reflect regional reinforced remove removing reported revealed role school scores section semi severity sided significance smith spared spatial specialization speculative statistical statistics stroke structural subject subjects suffering symptoms syndrome template threshold tissue tract tracts trend unilateral unit validated view volume volumes warped whether widespread years