Meeting Banner
Abstract #3699

In-Vivo Detection of Intracortical Myelinated Fibers in Human Hippocampal Formation: Submillimeter Resolution Diffusion Tensor Imaging Compared with Histological Findings

Takashi Yoshiura1, Akio Hiwatashi1, Satoshi Suzuki2, Tsuyoshi Okamoto3, Osamu Togao1, Koji Yamashita1, Kazufumi Kikuchi1, Hiroshi Honda1

1Department of Clinical Radiology, Kyushu University, Fukuoka, Japan; 2Department of Neuropathology, Kyushu University, Fukuoka, Japan; 3Department of Advanced Medical Initiatives, Kyusuh University, Fukuoka, Japan

Intracortical myelinated fiber (ICMF) is an essential component to characterize microarchitecture of the cerebral cortex. Our purpose was to test the feasibility of in-vivo detection of ICMF in the human hippocampal formation by high-resolution diffusion tensor (DT) imaging. DT images of the hippocampal formation were obtained with an in-plane resolution of 0.85 mm. Fractional anisotropy (FA) in 3 different cortical subregions were compared. FA in subiculum was significantly higher than those in the other regions, which was in accordance with histological findings in myelin-stained specimens. Results suggested that in-vivo detection of ICMF using high resolution DT imaging is feasible.

Abstract PDF E-Poster Video

Keywords

abundant according acquisition advanced affect affecting aging among anatomy anisotropy approximately array arrow averaging axis best body called cerebral channel characterize characterizing clinical close coded coil color comparable component confirmed corresponded cortex cortical create dense denser density detecting detection diagnosing diffusion directional disease diseases drawn dual early eleven encoding epilepsy essential evaluation example feasibility feasible fiber fibers field findings formation fractional gold gray head healthy histological human in vivo initiatives inspection interpolation japan known least lobe long maintain male mapping materials matrix measured medical modified neurological neuropathology notice observe pathological pathway patients perpendicular pixel placed planar prepared previously primarily proposed quality quantitatively quasar radiology reducing represent required resolution respectively revealed running scale scaled scanner sense shot significance significantly slices slide slides spatial specimen specimens square stage stained steps student studied subjects suggested systems temporal tensor thick typical useful version view virtual visualization whole years