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Abstract #3690

DCE-MRI for Assessing Antiangiogenic Drug Effect in a Mouse with Choroidal Neovascularization

Jae-Hun Kim1, Ji Hoon Cha1, Geun Ho Im2, Julius Chung3, Jung Hee Lee1

1Department of Radiology, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of; 2Center for Molecular and Cellular Imaging, Samsung Biomedical Research Institute; 3Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University

Dynamic contrast-enhanced magnetic resonance imaging provides parameters indicating permeability of tumor microvessels which has been shown to be closely related to angiogenesis. In this study, we tested that DCE-MRI can provide a non-invasive imaging biomarker to evaluate anti-angiogenic efficacy of macular degeneration. Our results demonstrated that there were significant changes between permeability parameters computed from drug treated and control group at 14 days (P < 0.01). These findings show the feasibility of permeability parameter as noninvasive biomarker for antiangiogenic drug evaluation in a mouse with choroidal neovascularization

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Keywords

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