Meeting Banner
Abstract #3666

Resting State Functional Connectivity in Tuberous Sclerosis Complex and Refractory Epilepsy

Ahmad Mohamed1, 2, Richard Masterton2, 3, John Archer2, 3, David Abbot2, 3, Michael Kean4, Simon Harvey1, 3, Graeme Jackson2,<su

1Department of Neurology, Royal Children's Hospital, Melbourne, Victoria, Australia; 2Brain Research Institute, Melbourne, Victoria, Australia; 3Department of Medicine, University of Melbourne, Victoria, Australia; 4Medical Imaging Department, Royal Children's Hospital, Melbourne, Victoria, Australia

This study aimed to test if functional connectivity (FC) can be used to differentiate epileptogenic from non-epileptogenic cortical tubers in four children with tuberous sclerosis complex and refractory seizures. FC was assessed using partial correlation between band-pass filtered (0.01-0.1 Hz) fMRI signal time-courses averaged within regions-of-interest placed in tubers, thalami and posterior default mode network (DMN) regions. No statistically significant difference in tuber-tuber, tuber-thalami and tuber-DMN FC was noted at either individual or group level. The few subjects, imaging under general anaesthesia and lack of simultaneous EEG recording potentially limit the study.

Abstract PDF

Keywords

abbot account activity affected aimed analyses anesthesia anesthesiology assess assessed band bilateral blue bold boys brain breakdown children clinical comparing complex component components concentration confounds connectivity consciousness correction correlation cortex cortical coupling courses covered create created decreased default depth details differentiate dilute discharges distinguished electrodes epileptic filtered finally fluctuation fluctuations focal functional general highlights hospital identified identify immediately improve included inclusion individual induced inferior influence institute john known larger lateral limitations localization localized longer loss manner manually masks medical might minutes modulate monitoring months motion negative network networks neurology none object onset outlined overlaid parietal partial parts pass patient patients patterns placed positive posterior potentially practice prior processed realignment recorded refractory related reliably rest resting royal sample scanned sclerosis screened seeded seizure seizures several slice smith smoothing spasms spatial spike spontaneous strength studies subject subjects summary surface table thalami true tuber tuberous tubers types unclear varying visual white whole years yellow