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Abstract #3662

A Whole-Brain Network Analysis in Patients with Hereditary and Acquired Peripheral Neuropathy

Maria A. Rocca1, Paola Valsasina1, Raffaella Fazio2, Stefano Previtali2, Elisabetta Pagani1, Andrea Falini3, Giancarlo Comi2, Massimo Filippi1

1Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy; 2Department of Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy; 3Department of Neuroradiology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy

We assessed functional connectivity (FC) at resting state (RS) in 25 patients with acquired (A) and hereditary (H) peripheral neuropathy (PN). Compared with controls, PN patients showed decreased FC in the secondary visual network and increased FC in the auditory network. Moreover, APN patients showed decreased FC in the motor, default mode and salience networks. Conversely, increased FC was found in the salience network of HPN patients. Enhanced inter-network connectivity among sensory and motor networks was found in both PN patient groups vs. controls. Such an enhancement was more evident in HPN than in APN patients.

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Keywords

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