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Abstract #3652

Evidence for Typical and Atypical Gray and White Matter Pathology in Frontal Lobe Epilepsy and Different Types of Temporal Lobe Epilepsy

Susanne G. Mueller1, Karl Young, Michael M. Weiner, Kenneth D. Laxer2

1Center for Imaging of Neurodegenerative Diseases, San Francisco , CA, United States; 2Pacific Epilepsy Program, California Pacifc Medical Center

Synopsis: Voxel-based image analysis approaches, demonstrated different, characteristic abnormality patterns different types of non-lesional partial epilepsy. It is unknown to what degree these patterns exist in individual patients. A two-level multi-modality imaging Bayesian network approach is used with the following aims: 1. to characterize the subtype specific structural abnormalities in non-lesional TLE-MTS, TLE-no and FLE using GAMMA. 2. to the second-level Bayesian network which allows for a robust imaging based subtype classification of single subjects by combining the information obtained at the first level. 3. to identify typical, e.g. FLE gray, and atypical patterns in TLE-MTS, TLE-no and FLE.

Keywords

abnormalities abnormality absence address advantage allows approaches associations assumptions atrophy atypical background belief binary brain candidates chances characteristic classification classified clustering clusters combination combined confidence considered control controls corrected correctly correspondence counterparts damage decrease degree detailed determine develop differ diffuse dimensional diseases duration epilepsy evidence exam features field findings flipped form frontal function gamma generate generated generating graphical gray hemisphere highly hippo identify implemented important individual input label labels laxer least linear lobe loss magnet maps medial medical membership modalities modality model motion multiplied network noise none onset original pacific parametric partial pathology patients pattern patterns population presence probabilistic probability processed produces pronounced propagation propose question random regarding registration remainder remaining represent require resolution sclerosis scores seizure seizures side sided similarly smoothed spatially spec statistics subject subjects subtype symmetrical template temporal though threshold thresholding thresholds tools type types typical unbiased uncertainty unknown variable violate volumes warped warping white whole years young