Meeting Banner
Abstract #3648

Brain Diffusion and Perfusion Alternations in Chronic Obstructive Pulmonary Disease (COPD)

Geon-Ho Jahng1, Chang-Woo Ryu1, Min-Ji Kim1, Hyug-Gi Kim1, Sun Mi Kim1, Dal Mo Yang1, Dong Wook Sung2, Woo-Suk Choi2

1Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea, Republic of; 2Radiology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea, Republic of

A cognitive deficit is a common problem in patients with chronic obstructive pulmonary disease (COPD). To prospectively evaluate if MRI can demonstrate the microstructural volume loss, the diffusion and/or cerebral blood flow (CBF) changes in subjects with COPD compared with cognitively normal (CN) elderly subjects, 6 subjects with severe COPD, 13 with moderate COPD, and 12 CN subjects underwent isotropic volumetric T1-weighted imaging and diffusion tensor imaging (DTI), and arterial spin labeling perfusion imaging. Voxel-based statistical analyses among groups were performed on brain volumes, fractional anisotropy (FA) and trace, and CBF by ANOVA tests.

Abstract PDF E-Poster Video

Keywords

acknowledges addition affairs altered alternations although among analyses angular anterior applied arch arterial attenuation axial basal best bilateral brain cerebral chronic classified clusters cognition cognitive cognitively common computed contiguous contrast control controls correlated correlation cortex cortices decrease decreased demographic despite detection diffusion discovery disease documented dong early encoding enrolled evaluate evaluation evaluations extensive extent false family finally finding flair fluid frontal function ganglia grant gray health hospital impairment importance important incomplete index inferior integrity inversion isometric known lateral least little lobes mainly many maps measures medial medical middle might ministry moderate neurology nucleus obstructive occipital parametric parietal patients perfusion planar potential previous problems proceedings processing project proper psychiatry pulmonary radiology recovery reduced regional republic reserve sever severe severity shot significantly spin star statistical steps structural subject subjects suggested sung superior supported system technology temporal tensor tomography tool trace tract understanding underwent useful version volume volumes volumetric welfare white women yang years