Diffusion Basis Spectrum Imaging Detects Evolving Axonal Injury, Demyelination and Inflammation in the Course of EAE

Keywords

according acquisition active acutely anisotropic apparent appears autoimmune axial axon basis brain cell cells chemistry chronic chronics clinical combination component components considers cord correlate corresponded course cross damage days decreased denotes derives detected detects diffusion diffusivity disease dorsal edema equation event events evidences evolving except experimental female findings fixed fraction fractions gradient green highest histological histology hours identified immunization in vivo indicate indicating induced infiltration inflammation injury integrity intensity introduced isotropic lateral leave lesions letters likely limits linear localized loss lots lumbar maps markers marks material matrix mice model mouse neurology neuropathology novel obvious onset pathologies peak peptide perfusion permanent physics post presence principal quantification quantified quantify radial radiology recently reflect reflects represent resolve response restricted retreat returning revealed reversible rodent saint sclerosis score scores sectional segments severe significantly slice song spatial spectrum spin spinal strongly substantiated successfully suggest suggests temporal tensor tensors tissue together tract validation validations ventral water weeks white yellow