Meeting Banner
Abstract #3593

Comparison of in vivo Human, in vivo Macaque and ex vivo Human Measurements of Diffusion Orientation in the Cerebral Cortex

Jennifer A. McNab1, Jonathan R. Polimeni1, Ruopeng Wang1, Jean C. Augustinack1, Kyoko Fujimoto1, Allison Player1, Christina Triantafyllou1, 2, Thomas Janssens3

1A.A. Martinos Center for Biomedical Imaging, Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; 2A.A. Martinos Center at the McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States; 3Laboratory for Neuro- and Psychophysiology, K.U. Leuven Medical School, Campus Gasthuisberg, Leuven, Belgium; 4Harvard-MIT Health Sciences and Technology Division, Massachusetts Institute of Technology, Cambridge, MA, United States

We compare cortical diffusion anisotropy in in vivo human (1 mm iso), in vivo macaque (0.7 mm iso) and in ex vivo human tissue (0.5 mm iso). All data sets show radial diffusion in M1 and tangential diffusion in S1, although the ex vivo human data also shows some regions of radial diffusion in S1.

Keywords

acquisition agreement aligned anesthetized anisotropy appeared attempt axial bias biomedical blueprint boundaries boundary brain built campus careful cerebral characterized close closely coil computed consisted containing contamination control coronal corpus correct correction corresponds cortex cortical cortices custom dale definition depth described detected diffusion disease division eigenvector embedding equipped evenly exhibits family flash fluid frame funding general generated gradient grant gray head health healthy hemisphere history hospital human implanted in vivo index inner insert institute interestingly intermediate isotropic iterations laboratory laminar library limit macaque male manual many masked matrix medical monkey motion much observations orientation outer partial patterns player pons principal prior product prone protocols psychophysiology radial radiology radius receive recently reconstruction reconstructions registered registration reliably remains required resolution sample scanned school selection sensory shot skull slew slices software source spaced spatial species specimen stopping stripping surface surfaces surgically system tangential technology tensor thinner threshold throughout tissue trio unclear underlying unfortunately vector volume volumes whole