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Abstract #3530

High SNR DCE Imaging for Whole-Brain Perfusion Assessment

Philippe Gauderon1, 2, Marina Salluzzi, 23, Michel Louis Lauzon, 23, Michael Richard Smith, 14, Richard Frayne, 23

1Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada; 2Seaman Family MR Research Centre, Calgary, Alberta, Canada; 3Radiology, University of Calgary, Calgary, Alberta, Canada; 4Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada

A fast 3D SPGR sequence is suitable for dynamic contrast enhanced (DCE) cerebral perfusion imaging is demonstrated. As a proof of concept, the investigation validated the suitability of the imaging sequence for quantitative perfusion imaging using a static phantom. Perfusion maps generated from initial in vivo acquisitions were in agreement with literature values. The main shortcoming of the sequence was the low contrast-to-noise ratio (CNR) in cerebral tissue, though this concern was somewhat mitigated by increasing TR and using other approaches to preserve temporal resolution.

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Keywords

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