Meeting Banner
Abstract #3502

Uncertainty in the Pharmacokinetic Analysis of a Modified Reference Region Model Using Dynamic Contrast-Enhanced MRI

Yen-Peng Liao1, Chi-Jen Chen1, 2, Ho-Ling Liu3

1Department of Medical Imaging, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan, Taiwan; 2Department of Medicine, Taipei Medical University, Taipei City, Taiwan, Taiwan; 3Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan County, Taiwan, Taiwan

A modified reference region (mRR) model including vascular term for dynamic contrast-enhanced MR imaging (DCE-MRI) can quantify physiological parameters without the need of an arterial input function (AIF). However, inaccurate assumptions of the parameters of a reference region (RR) may induce large estimation error in the quantification of a tissue of interest (TOI). This study aimed to assess the uncertainty in the pharmacokinetic analysis with a mRR model using computer simulations. The results showed estimation errors of [+41.8 to -17.08], [+47.85 to -21.08], and [+37.67 to -24.33] for [-30% to +30%] variations on inaccurate K trans,RR, ve,RR and vp,RR , respectively.

Abstract PDF E-Poster Video

Keywords

accuracy aims applications applied apply arterial assumption assumptions back basic cause caused city clinical coefficient common concentration condition constant contrast converted county critical critically curve curves derived dynamic enhanced error errors estimation evaluate extracellular feasible fixed fraction free function future generated gradient hospital inaccurate individuals influence input inputs kinetic limited ling literature mainly materials medical medicine might model modeled modified muscle noise noisy parker part percentage phenomenon phys physiological plasma population proposed pulse quantification quantified radiological report required respectively runs sciences shares simulated simultaneously skeletal space spoiled stable studies suggest supply term thousand tissue tissues trans transfer tumor unavailable uncertainty variation variations varied vascular volume