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Abstract #3372

Comparison of Tissues Characterized by CEST Spectra at 7T

Kimberly L. Desmond1, Greg J. Stanisz1, 2

1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada

The nature of the endogenous CEST Z-spectrum was examined at 7T in six anatomical regions / tissue types in mice: muscle (In Vivo and ex vivo), grey matter, white matter, adipose, bladder and tumour. CEST images were acquired for a range of offset frequencies from -2000 to 2000 Hz (6.71ppm) and the shape of the spectrum was observed as a function of amide proton exchange, hydroxyl proton exchange and the presence of mobile lipids.

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Keywords

academy acidosis acquisition addition additional adipose adjust allow amide amplitude animals applied around attempts attribute basis bearing beyond biomedicine biophysics bladder broad carcinoma causes cell characterized chemical complicates concentration confound consisted consistent contributing correct correction correlated decomposed definition density determining direct distinguish drift duration echoes emphasizing ends environment essential evidenced exchange exchanging existing exploration extent fact fast features fitting flash frequencies frequency functions generated gradient gray haver hydroxyl in vivo included incorrectly indicative influence inhomogeneities institute interspersed involve lactic lewis ling lipid lipids mainly maps measured measuring medical medicine metric metrics mice mobile muscle national nearby negative neural notable offset optimization pathology peak peaks place platform potential presence procedure proceedings properties proton protons pulse rats reach readout rectangular related reliable resolution retrospective sacrifice saturation sciences sensitive several shapes since slice spectra spectrum speculate spin spoiled strong susceptibility throughout tissue tissues transfer treatment typically urea usage valuable visible water wealth white wide width wise