Meeting Banner
Abstract #3368

Quantitative Imaging of Selective Relaxation Component in Cartilage

Weitian Chen1, Mai LH Nguyen2, Garry E. Gold2

1Global MR Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 2Radiology, Stanford University, Palo Alto, CA, United States

Recently multi-exponential relaxation analysis was reported to have improved specificity of matrix assessment in cartilage. However, quantification of more than one component of T1rho or T2 significantly increases scan time and is impractical in clinical applications. We investigate mono-exponential relaxation methods to quantify relaxation property of a single relaxation component by suppressing signal from other components. Such methods are feasible in terms of clinical scan time, and have potential to achieve improved specificity to matrix component in cartilage compared to conventional mono-exponential relaxation analysis.

Keywords

accurate achieve acquiring actual additional advantages alto among anatomy applied applying approaches approximation arrows assessment away blood blue care cartilage cause channel check choice clinical clinically closer coil collect collected collection common component components composition consent consist contrast convenient created decay decays decrease degradation degree dependency despite detection diagnostic discovery disease early eight exam excessive existence experiences exponential feasible fitting flair gold great hardware illustrated impact impractical improve improved improvement in vivo inapplicable inserted interfere intermediate invasive inverted investigate knee laboratory length limitation long longer magic magnetization mapping matrix measured might model modification mono much note nulling obvious orientation osteoarthritis park particular phantom phantoms potential prep prepped preserving prevalent previously progressive property proposed pulses quantification quantify quantitative radiology rather receive recently reduce relates relatively reported scanner selected selective sets setting short significantly simply specificity spiral start subject subtract subtraction suppress suppressed suppressing suppression theory tissue transmit turned ultrashort useful usually vessels whereas whether