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Abstract #3342

Microscopic Magnetic Resonance Imaging (MRI) Assessment of Trabecular Micro-Architecture in Non-Osteoporotic Post-Menopausal Women with and Without Fracture

Richard Kijowski1, Michael Tuite1, Diane Krueger2, Michael Kleerekoper3, Neil Binkley2

1Radiology, University of Wisconsin, Madison, WI, United States; 2Medicine, University of Wisconsin, Madison, WI, United States; 3Medicine, St. Joseph Mercy Reichert Health Center, Ypsilanti, MI, United States

Microscopic magnetic resonance imaging (MRI) of the wrist was performed on 18 post-menopausal women with normal or osteopenic bone mineral density (BMD) who had a history of low energy fracture and a control group of 18 age, race, and ultra-distal radius BMD-matched postmenopausal women with no history of fracture. The ultra-high resolution images were used to measure trabecular micro-architecture parameters using a semi-automated virtual bone biopsy system. Post-menopausal women with fracture had significantly lower (p<0.05) trabecular bone volume fraction and surface-to-curve ratio and significantly higher (p<0.05) erosion index than women without fracture.

Keywords

ability absence account architecture assess assessment automated better biopsy birdcage blood body bone chemistry clinical coil conditions consisting control counterparts curve curves demographic density described designed diagnosis diagnostic digital dimensional disease distal distance distinguishing dominant dual eighteen elevated elliptical energy enhance erosion excitation experienced fails fast femur field fraction fracture funding future fuzzy generate grant health height hence history identify impaired include included index indicative individuals influence insight institute investigated laboratory link lumbar mapping maps mass matched matrix measure measured medicine menopausal mercy micro microscopic miner minute model network noiseless older osteoporosis panel parametric plates post potentially prevention previous previously processing produce proximal race radiology radius rank represented respectively risk routine scanner scores semi served signed significantly slice specially spin spine strength struts studies suggests superior surface surfaces system systemic table targeting technologist therapy third thirty tissue topological trans transform translational ultra underwent variables various view virtual volume women wrist years