Meeting Banner
Abstract #3339

Hyperintense Signal from Craniofacial Bones in SWIFT Images of Fetal Mouse

Jinjin Zhang1, Djaudat Idiyatullin1, Vladimir Leon Salazar2, Curtis Corum1, Michael Garwood1

1Center of Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Div. of TMD and Orofacial Pain, University of Minnesota, Minneapolis, MN, United States

The detection and accurate prenatal diagnosis of skeletal dysplasia remain problematic with ultrasonography. Although MRI can be used to diagnose some fetal musculoskeletal abnormalities, studies using MRI to image fetal bones directly are limited. Here, SWIFT, which is sensitive to short T2 signals, was utilized to image craniofacial bones and to measure the T1 of a fetal mouse head. Due to the near absence of T2-weighting, SWIFT images display close to pure T1-weighted contrast. The feasibility of SWIFT to allow qualitative and quantitative evaluation of fetal skeleton makes it a powerful complement to ultrasonography for the detection and diagnosis of skeletal dysplasia.

Keywords

abnormalities absence acknowledgments acquisition aims allowed although anatomy anomalies appear approximate arrows assoc bandwidth bone bones bony brain coil comparable complementary compositional computed console contrast days delineate delineation despite detect detection development diagnose diagnosis diameter differing difficult dose double early easy edge equation evaluate even excitation experiment exposure feasibility fetal fetus film fitting foundation fresh funded furthermore gestation gradient grants head home indicative intensity invisible known linear longer longitudinal loop loss made magnet mainly makes materials matrix mature measured micro minutes mouse must nearly nominal nose optimize oxford pain parts performance placed play possibly potential prenatal problematic profiles projections promising protocols proton quality quantify radiology remain risk role sample saturated scanner sections selected short simultaneous skeletal skeleton skull slice slightly soft sometimes specimen spine spins spokes springer stage structures studies suggests summary superior surface sweep swift tissue tissues tomography transform transverse ultrasound undeveloped useful utilized variation visible visualize voltage water yields