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Abstract #3327

Longitudinal Changes in T1ρ at Adjacent Level Discs

Matthew Fenty1, Catherine DeBrosse2, Rachelle Crescenzi2, Dawn Squillante3, Philip M. Maurer3, Dawn M. Elliott4, Ari Borthakur1

1CMROI, Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States; 2Department of Biochemistry & Molecular Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA, United States; 33B Orthopaedics, Philadelphia, PA, United States; 4Department of Bioengineering, University of Delaware, Wilmington, DE, United States

In this study, we use T1ρ as a quantitative biomarker to assess discs adjacent to surgically removed discs two years post-surgery. We further evaluate whether these changes in T1ρ were related to pre-surgical discography opening pressure or T2-MRI based Pfirrmann degenerative grades of the same adjacent discs. Pre-surgical opening pressure measurements of adjacent discs were significantly related to changes in T1ρ pre- and post-surgery.

Keywords

adjacent agent apart approval array artifacts assessment back background better biochemistry bioengineering biomedical biophysics board cadaver classification clinical coil college condition confidence content continuing continuous contrast correlate correlation dashed dawn decreased degenerate degeneration detect develop diagnosis diagnostic digital disabling disc discography discs disease establish etiologic evaluate fluoroscopic free full funded fused fusion grade grades grading graph growing guideline height human hypothesis in vivo inability indicating indications individuals injected institutional intern internal intervals intervention invasive joint likely location longitudinal lumbar maps measured medical medicine merit milliseconds molecular motion motivation needles north novel opening osmotic overlaid pain panel patient patients physicians placement popularity post practice preserve pressure prevent procedures prone prosthetic provocative quantification quantitative radiologic radiology rapidly recorded recruitment registration related relationships reproducible responsive review risk school several slice society spine sponsors statistical strong subjects subtle suggests suppl supplied surgery surgical surgically symptoms threshold tissue tools treat treated treatment trio variety vendor whether written years