Using the Ionic X-Ray Contrast Agent Hexabrix as a Specific Marker for Cartilage Glycosaminoglycan (GAG) Content Via Chemical Exchange Saturation Transfer Imaging at 3 Tesla

Keywords

accumulate accumulation achieved additionally agent agents agreement alternative amide apparent assess assessment asymmetry basis bone bulk butcher cartilage channel charge charged chemical clear clearly clinical coil components concentrations confirm confirmed contain content contrast control corrected corresponds curves datasets degradation degraded delay delayed delineate density depleted determined diffuse divided duration early elementary encoding enhanced enzymatically evaluate evaluations every examinations examined exchange experiment exploited field fixed frequency fresh frozen furthermore gadolinium gain good gradient graduate healthy hydroxyl immersed in vivo inhomogeneities initial instead interpolated iodine ionic knee knees knowledge local loss magnetization marker materials matrix medical medicine mixture module molecules needed negatively osteoarthritis patterns pieces pixel placed plastic porcine potential previously protons pulse pulses radiology recorded reduced related repeated resolution saline samples saturation school selective sensitivity series sherry since smoothing sodium solutions spatial specificity spectra spline spoiled staining steps strongly subject sufficient suggest surrounding system theory thought tissue transfer treatment tubes veterinary vitro woods yields