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Abstract #3258

Quantitative Evaluation of Fat Infiltration in the Rotator Cuff Muscles Using Chemical Shift-Based Water/fat Separation

MAGNA25Dimitrios C. Karampinos1, Lorenzo Nardo1, Julio Carballido-Gamio1, Ann Shimakawa2, Benjamin C. Ma3, Thomas M. Link1, Roland Krug1

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 3Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, CA, United States

The evaluation of shoulder muscle fat infiltration is important for the clinical management of patients with rotator cuff injuries. Goutalliers classification of T1-weighted or proton-density weighted images has been traditionally used to evaluate fat infiltration in the shoulder muscles. However, this technique is semi-quantitative and therefore subjective and cannot track small fat infiltration changes. Chemical shift-based water/fat separation techniques have been recently implemented to measure fat content in skeletal muscle. In the present work, a chemical shift-based water fat separation is applied to the shoulder musculature of 31 subjects and the derived mean fat fraction quantitative measures are compared with Goutalliers classification.

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Keywords

absolute addition address advantageous applied arrows assess assessment bandwidth bias channel characterize characterizing chemical classification clinical coefficient coil compartments completely computation computed considered content correction correlated correlation corresponds coverage criterion critical cuff decision define defined degree density derived description differentiate discrimination elbow error errors establish evaluating evaluation example explanation fast fatty feasibility field fraction fractions global goals grade graded grades gradient grading heterogeneity ideal included individual induced infiltration intermediate introduced joint laboratory lateral link magnitude maintained making manually maps matrix medial minimize minor modeling much muscle muscles muscular noise objective oblique orthopedic outcome overcome park pathology patient peak permitted plus precision process proton quantitative radiologist radiology ranging recently reeder reliable remove representative reproducibility reproducible respectively rotator scale scales scanned scanner score segmented selection semi semiquantitative separation shoulder since slice slices spatial spectral spectrum spin spoiled streaks strongly subjectivity subjects supported surface surgeons surgery system treatment twice version view visible volume water