Meeting Banner
Abstract #3252

Intravoxel Incoherent Motion (IVIM) in Healthy Skeletal Muscle Pre- And Post-Exercise

Eric E. Sigmund1, Steven Baete1, Gene Y. Cho1, Dabang Sui1, Thompson Ukpebor1, Kecheng Liu2, Jane Kwon1, Kellyanne McGorty1, Jenny Bencardino1

1Radiology, NYU Langone Medical Center, New York, NY, United States; 2Siemens Medical Systems

Skeletal muscle pathologies can have both microstructural and microvascular underpinnings to which diffusion-weighted imaging can be made sensitive through the intravoxel incoherent motion (IVIM) approach. We performed IVIM in healthy calf muscles at 3 T both before and after treadmill exertion, and evaluated the biomarkers of tissue diffusivity, perfusion fraction, and pseudodiffusivity in 7 different muscle compartments and three orthogonal directions. The largest and most significant changes occurred for perfusion fraction, which isotropically increased by ~50%. Results are discussed in the context of muscle physiology and the sensitivities of diffusion contrast.

Keywords

abnormalities accumulate acknowledge affect alteration anisotropy apparent applied apply approved axes axial background beyond biophysical bipolar blood board channel coefficient coil collected commonly compartment consistent contrast decay decays degradation departure derived diffuse diffusion diffusivity dilation disorders disrupted distribution edema engorgement enlargement example exercise exertion explore explored extracted fitted flow fraction fractions fully function gradient gradients healthy highlights incoherent indicate indicates inferior inflammation institutional integrated isotropic jenny journal kinematic knee like little local magnet maps marker materials matrix medical medicine membrane metrics microscopically minimal minutes model monitoring motion muscle near occur orthogonal parametric pathologies pathology perfusion perhaps physiology post posterior potentially power powerful probed process protocol quantification radial radiology readout regime respective response rest review role scanner segment sensitive sensitivity sensitizing short skeletal slices smoothed software sources spin sports statistical stored strongly structural subjects sufficiently support syndrome table tensor thereby tissue treadmill underwent unilateral useful variants velocity volume volunteer volunteers wide written