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Abstract #3207

Assessment of Motor Impairment in Acute/subacute Stroke Patients with Diffusional Kurtosis Metrics

Edward S. Hui1, Wuwei Wayne Feng2, Ali Tabesh1, Leonardo Bonilha3, Jens H. Jensen1, Joseph A. Helpern1

1Dept of Radiology, Medical University of South Carolina, Charleston, SC, United States; 2Dept of Neuroscience, Medical University of South Carolina, Charleston, SC, United States; 3Dept of Neurology, Medical University of South Carolina, Charleston, SC, United States

Motor function impairment is a major complication following stroke, and a robust biomarker for predicting patient recovery of motor function could benefit clinicians decision making on rehabilitation planning. In this study, diffusional kurtosis imaging is investigated as a potential technique for improved assessment of stroke patients. For 10 subjects with acute/subacute ischemic stroke, a strong negative correlation (r = -0.89, p = 0.001) was found between the axial kurtosis in the corticospinal tract and clinical motor functioning assessment test scores.

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Keywords

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