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Abstract #3184

Evaluation of Gadolinium Concentration in Morphologic Assessment of Brain Tumors: Results of a Multicenter Intraindividual Crossover Comparison of Gadobutrol Versus Gadobenate Dimeglumine (The MERIT Study)

Guenther Schneider1, Josef Vymazal2, Marek Mechl3, Mayank Goyal4, Miroslav Herman5, Cesare Colosimo6, Mieczyslaw Pasowicz7, Robert Yeung8, Barbara Paraniak-Gieszczyk<s

1Diagnostic and Interventional Radiology, Saarland University Hospital, Homburg, Germany; 2MRI, Na Homolce Hospital, Prague, Czech Republic; 3Radiology, University Hospital, Brno, Czech Republic; 4MRI, Foothills Medical Centre, Calgary, Alberta, Canada; 5Radiology, University Hospital, Olomouc, Czech Republic; 6Radiology, Policlinico Agostino Gemelli, Rome, Italy; 7John Paul II Hospital, Krakow, Poland; 8Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 9NZOZ Slaskie Centrum Diagnostyki Obrazowej, "Helimed", Katowice, Poland; 10Hamilton Health Sciences, Hamilton, Ontario, Canada; 11Neuroradiology, Hospital San Raffaele, Milan, Italy; 12Neuroradiology, Hospital Niguarda Ca' Granda, Milan, Italy; 13Neuroradiology, University of Pavia, Pavia, Italy; 14Hospital de la Santa Cruz y San Pablo, Barcelona, Spain; 15Neurological Clinic, Prague, Czech Republic

In a prospective double blind intraindividual crossover study, 122 adult patients with known or suspected brain tumors were randomized to undergo two identical enhanced MR examinations within 3-14 days using 0.1 mmol/kg doses of gadobenate dimeglumine or higher-concentration gadobutrol (volumes of 0.2 mL/kg and 0.1 mL/kg, respectively). Three blinded neuroradiologists assessed images for qualitative (ie, lesion border delineation, disease extent, internal lesion morphology, lesion contrast enhancement, overall diagnostic preference) and quantitative (ie, contrast-to-noise ratio, lesion-to-background ratio) endpoints. Images acquired after gadobenate dimeglumine demonstrated greater morphologic information and lesion enhancement compared to gadobutrol. Safety findings were comparable for the two agents.

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Keywords

achieved administered adverse agent agents agreement apart assessment assessments background blinded border brain clinic clinical comparable concentration consistently contrast crossover days definition delineation despite diagnoses diagnostic disease dose doses double durations efficacy endpoint endpoints enhancement enrolled evaluable evaluated evaluation events examination examinations except expert expressed extent fast foothills gadolinium global good gradient greater health homburg hospital incidence included independent individual inflammation injection internal john known lesion materials medical melanoma merit metastases mild moderate morphologic morphology mostly neurological noise noted overall patients percent post preference preferred primary qualitative quantitative quantitatively radiologists radiology randomized reader readers received republic respectively safety sciences significantly site spin suspected table tumor tumors underwent versus visualization woman year