Meeting Banner
Abstract #3162

Effects of Gender and Music on Global Functional Connectivity Density at 4T MRI

Ruiliang Wang1, Gene-Jack Wang1, Rita Goldstein1, Elisabeth Caparelli1, Frank Telang1, Nora D. Volkow2, 3, Dardo Tomasi3

1Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States; 2National Institute on Drug Abuse, National Institute on Health; 3National Institute on Alcohol Abuse and Alcoholism, National Institute on Health

Using voxelwise resting-state functional connectivity density mapping here we demonstrate that music can increase the global functional connectivity density of the brain. EPI datasets from 113 healthy subjects were collected in resting conditions in a 4Tesla MRI scanner. Parallel computing techniques were used to speed up the computation of the gFCD (degree centrality) at 3 mm isotropic resolution. Standard parametric mapping techniques demonstrated a music-related enhancement of the gFCD in the motor cortex that was strongly correlated with music-liking scores and prominent gender effects affecting the short-range hubs in the default mode network and long-range hubs in the visual cortex.

Abstract PDF E-Poster Video

Keywords

abstract abuse acoustic acquisition addition affected alcohol alcoholism analyses attenuation auditory band blood bold brain calculation centrality classical cognitive compatible computed condition conditions connections connectivity contrast correlated correlation corroborate cortex cortices covariate datasets death default degree density dependent detectable determine dimorphism drug earplugs enhancement evaluate exhibited eyes females filtering fluctuations frank functional functions gender gene global gradient graph headphones health healthy hubs human hypothesis hypothesized immediately important institute interactions interference involves isotropic jack laboratory liked liking listened local location long males mapping maps measures medical minimal minimize mode motion motor much music national network noise normalized open pairs parallelism pass peer perception physiologic planar plays positive posterior pressure previously processing production realigned realignment regression regressions related removed reported resolution rested resting roles sample scanner scores sensory series short shot significantly simple smoothed sound space spatially speed stimulation strength subject subjects suggesting suite support supports theory threads variations visual whether whole workstation