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Abstract #3158

Investigating the Spatial Folding Pattern of Very Preterm Neonatal Cortex Scanned at Term-Equivalent Age

Andrew Melbourne1, Giles S. Kendall2, Manuel J. Cardoso1, Nicola J. Robertson2, Neil Marlow2, Sebastien Ourselin1

1University College London, London, United Kingdom; 2University College Hospital, London, United Kingdom

MRI has revealed a common imaging phenotype which has stimulated efforts to develop markers of outcome to guide mitigating treatment or therapy. This work analyses the cortical surface properties of 92 very preterm babies (born prior to 32 weeks gestational age (GA)). High-resolution T1-weighted term-equivalent MRI of very preterm neonates are segmented and the grey/white matter interface extracted. By correlating the cortical surface properties both globally and for each lobe we can investigate the spatial pattern of cortical folding. This reveals consistent spatial patterns in the cortical surface pattern.

Keywords

activations adaptive adult analyses anatomical anterior arbitrary atlas automated axis babies birth born boundary brain caption care cerebral class clearer coded cohort college color common complexity compound consistent controls coordinates correlated correlating correlation cortex cortical cross curvature define defined determine dimensional dimensionality disability discharge dominant emerging equivalent euclidean expectation extent extremely folding form frontal gender generic hemispheres highest histogram histograms hospital improve index individual infants intensive interface intersection investigate kingdom labeling lateral learned lobe lobes lobular looked macroscopic magenta major makes manifold medial modeling mostly multivariate neonatal neonates neurological nonlinear occipital opposing outcomes parietal pastel pattern patterns peaks phenotype plotted position posterior potential prematurely priors problems proceedings propagate properties property reduction reflect registration registrations remain represent resolution revealed risk routine scanned segmentation shape similarity simultaneously since space spatial strongly studies subject subjects subsequently surface survival symmetric target temporal term tissue trend trends unchanged underlying visually volume weeks white years yellow yields