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Abstract #3144

Altered Hippocampal Connectivity Network Associated with Impulsivity in Abstinent Heroin Addicts

Tianye Zhai1, 2, Chunming Xie, 12, Wenjun Li2, Zheng Yang1, Shi-Jiang Li2

1Center of Brain and Cognition, Beijing Institute of Basic Medical Science, Beijing, China; 2Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States

Neurobiological and neuroimaging studies have demonstrated that the hippocampus, as a major node of memory processing, is involved in drug addiction. However, little is known about the role of hippocampal network and its relation to drug-seeking behaviors such as impulsivity in addiction. In this study, we utilized resting-state functional connectivity fMRI (R-fMRI) to investigate the alteration of hippocampus functional connectivity (HFC) network and its relation to impulsivity in abstinent heroin dependent subjects (HD) and control non-drug users (CN).

Keywords

abstinent accordance addiction addicts alteration altered analyzed anatomical anterior applied approved atrophy band basic behaviors bilateral biophysics blue brain bright china closed cluster coefficient cognition cognitive college color conducted connectivity consequence control corrected correcting correction correlates correlating correlation cortex course covariance damage dataset datasets declaration decreased dependent determined discarded discrete distinct distribution drug dysfunction eighty ethics existed eyes filter five fluctuation frequency frontal functional grant grants gray head healthy heroin identify impulse impulsive indicates individual inferior institute instructed investigate involved keep known little located long manually matched matrix measured medical middle ministry motion motor negative network neural neuron node normalized nucleus parietal participated pattern patterns people physiological pole positive posterior preprocessing prior relation represent resolution resting role sample scale scanner science scores seed seeking served shot sides significantly slice software space stable statistical strength studies subject subjects superior technology temporal thalamus transformation underpinnings understanding users utilized ventral volume whole written yang