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Abstract #3139

DTI Abnormalities in Pediatric Obsessive Compulsive Disorder

An Vo1, Patricia Gruner1, 2, Toshikazu Ikuta1, 2, Bart Peters1, 2, Anil K. Malhotra1, 2, Peter B. Kingsley3, Aziz M. Ulug1, Philip Szeszko

1Feinstein Institute for Medical Research, Manhasset, NY, United States; 2Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, United States; 3Radiology, North Shore University Hospital, Manhasset, NY, United States

Obsessive-compulsive disorder (OCD) is a disorder of the brain and behavior that is characterized by recurrent worries and repetitive behaviors. Pediatric OCD is similar to OCD in adults. However the content of obsessions and compulsions can be influenced by developmental factors such as age, gender, genetics. Neuro-imaging studies have contributed to our understanding of the neurobiological basis of pediatric OCD. The purpose of this study was to use diffusion tensor image (DTI) derived metrics to explore disease affected circuits in pediatric OCD patients compared to healthy volunteers.

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Keywords

abnormalities acknowledgments acquisition adolescent adults affected anisotropy anterior basis behavior behaviors brain bundle bundles chapter characterized child circuits clinical cluster clusters compulsions compulsive considered content contributed control controls coordinates corpus correction counted counts cutoff derived determined developmental diffusion disease disorder dysfunction entire explore extent fiber focal foundation fractional franklin gender genetics glen going healthy hillside hospital included influenced institute international lobe magma maps matched matrix maturation medical metrics north oaks obsessions obsessive occipital oxford part particular passing pathology patients pediatric peter peters post press protocol psychiatry radiology reconstructed recurrent registered relate repetitive reviews scanner seed seeds shore slices snider software student studied studies subjects suppl support supported table template tensor threshold tract tracts understanding volume volumes volunteers white wise worries zero