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Abstract #3136

Brain Tissue and Microstructure Alternations in Children with Trichotillomania

Geon-Ho Jahng1, Jee A Lee2, Min-Ji Kim1, Hyug-Gi Kim1, So-Youn Shin1, Geon-Ho Bahn2, Sun Mi Kim1, Chang-Woo Ryu1, Dal-Mo Yang1, Dong Wook Sung3,

1Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea, Republic of; 2Psychiatry, Kyung Hee University Hospital, Kyung Hee University, Korea, Republic of; 3Radiology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea, Republic of

Trichotillomania (TTM) is a poorly understood disorder that is characterized by repetitive hair pulling. Very few neuroimaging studies have been conducted on patients with TTM. No study has investigated neural correlates, such as grey matter and diffusion alterations, in patients with TTM. The objective of this study, therefore, was to investigate specific brain tissue loss with structural MRI and microstructural changes with diffusion tensor MRI in children and adolescents with TTM. Pediatric subjects who met criteria for TTM (n = 9) and age-, sex-, handedness-, and intelligence quotient-matched healthy controls (HC) (n = 10) were recruited.

Keywords

abnormalities acknowledges acquisition adolescent affairs alterations alternations applied arch attention best blue brain central chamberlain characterized children color compulsive concept contiguous control correlates covariate created decreased density diffusion dimensional disorder disorders distress dong encoding episodic examine family females finally finding findings frontal full functional fusiform gradient grant gray hair health highly hospital identified imagery impairment impulse inferior integrated intelligence investigate investigated isometric kernel leads lingual lobe loss magnetization major males mapping maps mechanisms medial medical middle ministry modalities neural normalization normalized obsessive onto overall overlapped parametric parietal patients pediatric poorly portion possibility post prepared previous processing project psychiatry pulling putative quotient radiology rapid recently rendering repetitive reported republic retrieval role sample selective self shares shin shot smoothed social software spatial spatially spectrum spin statistical structural studies subjects suggest summary sung support supported syndrome system tasks template temporal tensor thresholds tissue trace transformation understood version volume volumetric white wide width yang years