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Abstract #3134

Resting-State Functional Connectivity Changes Induced by Sleep Deprivation

Iris Y. Zhou1, 2, Russell W. Chan1, 2, Abby Y. Ding1, 2, Frank Y. Lee1, 2, Ed X. Wu1, 2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China

Sleep deprivation (SD) is known to diminish alertness and impair cognitive performance in humans. The intrinsic connectivity during resting-state may also be modified by SD. In this study, we used rsfMRI to examine the changes in functional connectivity induced by rapid eye movement SD in rat brains. After SD, interhemispheric correlations in hippocampus prominently diminished, indicating possible neuronal loss or/and neuronal dysfunction. Reduced intercortical connection in visual cortex was also observed, consistent with earlier studies showing decreased neuronal activity in this region after SD.

Keywords

activation activations affected alertness alterations altered animal apart atlas autism available behavioral brain china coefficients cognitive coil component confirmed connection connectivity considered consistent controlled corrected correlated correlation correlations cortex cross crosses decreased default deprivation diagnosis diameter diminish ding diseases easily electrical electronic employed engineering essential evaluation examine excitability filtered frank front functional furthermore gift green hand hong human humans identify impair impairment increasingly induced insights intrinsic investigate iris known labeled laboratory lasted lastly learning loss maps matrix memory middle mode model monitoring move network networks neural neuronal night nine paired paradigm people performance placed platform platforms possibly preparation primary prolonged rapid rare rats reached recent reduced reduction reflecting registered regulating remained reported republic resting reversible rodent role schizophrenia seed severely shot sleep slice software statistical stimulate strongly structure subjected suggesting suggests suppressed surface task thick timing toolbox training treatment treatments typical unchanged underlying validation variety various velocity video visual water weeks