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Abstract #3131

Resting State Network Changes in Pediatric OCD

An Vo1, Patricia Gruner1, 2, Toshikazu Ikuta1, 2, Miklos Argyelan2, Bart Peters1, 2, Anil K. Malhotra1, 2, Peter B. Kingsley3, Aziz M. Ulu

1Feinstein Institute for Medical Research, Manhasset, NY, United States; 2Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, United States; 3Radiology, North Shore University Hospital, Manhasset, NY, United States

Obsessive-compulsive disorder (OCD) is an anxiety disorder characterized by distressing, irrational thoughts and repetitive behaviors. Although pediatric OCD is similar to OCD in adults, the content of obsessions and compulsions can be influenced by developmental factors such as age, gender, and genetics. Ritualistic washing, repetitive checking, ordering, counting and hoarding are common compulsions in children and adolescents. Neuro-imaging studies have contributed to our understanding of the neurobiological basis of pediatric OCD. The purpose of this study was to use resting state fMRI to explore disease affected brain networks in pediatric OCD patients compared to healthy volunteers.

Keywords

abnormal acknowledgments acquisition activate adolescent affected although anterior anxiety basal basis behaviors brain carried causing certain characterized checking child circuits clinical closed cognitive combination common completed component components comprising compulsions compulsive compulsively computed conceivably conflict connectivity consisted contributed control controls correction cortical counting decomposed decrease description detecting determined disease disorder distressing dividing dual duration dynamics engage error especially explore expression extraction eyes findings foundation franklin frontal functional ganglia gender genetics gift glen healthy hillside hoarding hospital identify included independent indicate influenced input institute instructed intensity international irrational kernel length likelihood linear logistic maps matched matrix medical model motion network networks neurology nominal normalized north oaks obsessions obsessive oxford patients pattern pediatric peters play post preprocessing processing product psychiatric psychiatry radiology registering repetitive resting reviews role sample scanner scores selected separation series shore slice slices smoothing snider software spatial structural studies subject subjects subset supported table taking template understanding volumes volunteers yielded