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Abstract #3124

Functional Connectivity Abnormalities and Cognitive Impairment in Relapse-Onset Ms Patients: A Whole-Brain Functional Network Connectivity Analysis

Maria A. Rocca1, Paola Valsasina, Paolo Preziosa, Gianna Riccitelli, Vittorio Martinelli2, Andrea Falini3, Giancarlo Comi2, Massimo Filippi

1Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy; 2Department of Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy; 3Department of Neuroradiology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy

In this study, we assessed functional connectivity (FC) at resting state (RS) within and among cognitive networks in 30 healthy controls, 30 patients with relapsing remitting multiple sclerosis (MS) and 30 patients with secondary progressive MS. Decreased FC was present in frontal, temporal, parahippocampal and cerebellar regions of all cognitive RS networks, whereas increased FC was found only in the anterior cingulate cortex of the executive control network. Such abnormalities were detected in both patient groups, and they were more evident in the progressive form of the disease, as well as in patients with cognitive impairment.

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Keywords

abnormal abnormalities acknowledgments altered among anterior assess assessed blue bold brain cerebellar cerebellum characterized clinical cognitive cognitively component connection connectivity control controls coordinates corpus corrected correlated correlation correlations cortex damage decreased default deficits details detected diagram diffusion disability dysfunction error executive experimental explore expressed family frontal functional grant healthy highlighted identify impaired impairment independent indexes inferior institute inter interaction interactions intra light maps maria matched matching middle mode model moderately network networks neurology objective onset orange partially patients patterns positive preserved previous procedure produced progressive pronounced ranging relapse relapsing remitting rest resting salience salute scientific sclerosis score secondary selected severe space spatial structural studies subjects superior supported table template temporal tensor thresholded toolbox tracts unit variables vita white whole wise yellow