Segmentation of a Novel Lesion Type from MTR Images for Multiple Sclerosis Clinical Trials

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abstract according acquisitions activity acute additionally adequately adjust adult allow analyze anatomical annals appearing appropriate arrows artifacts assessing assessment automatically barrier basis blue brain brown calculations causing central clinical collected content contour corrected correlation criteria decrease decreased detect diagnosis disease diseases drop easy efficacy eliminate enhancement enrolled enrollment especially evaluate example exhibiting false filtered fluid frequency gadolinium greater growing head identified identify impairment important included indicate indicated indicates inflammatory inform larger least lesion lesions lifetime limiting longitudinal loss lost magnetization manually many marker masks measure measures metric metrics minimal nervous neurological neurology nonspecific normalized notoriously novel part particularly percentile pivotal positives potentially power powerful prevalence process produced producing promising quantify readers real reduces reducing regarding relapsing remitting repair require required requirements requires role sample scanners sclerosis segmentation segmented sensitive simple since slice smaller specificity subjects subtraction successive surrogate table taken tissue trained treatment treatments trial trials type version volume white zoomed