Meeting Banner
Abstract #3110

Infection with HIV and HCV Is Associated with Neurometabolic Compromise: A 3T Magnetic Resonance Spectroscopy Study

Rajakumar Nagarajan1, April Thames2, M.Albert Thomas1, Manoj K. Sarma1, Tim Arentsen3, Sapna Patel2, Elyse Singer4, Charles H. Hinkin2

1Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States; 2UCLA Department of Psychiatry; 3West Los Angeles VA; 4UCLA Department of Neurology

Hepatitis C virus (HCV) can damage not only the liver but also the brain. HCV infection is more serious in persons with co-infection human immunodeficiency virus (HIV). Magnetic resonance spectroscopic Imaging (MRSI) enables the noninvasive measurement of biochemical information in vivo. We have evaluated the two-dimensional (2D) MRSI using a 3T MRI/MRS scanner and the LC model quantitation of metabolites. Our pilot findings demonstrate significantly decreased N-acetylaspartate (NAA) and increased choline in the HCV patients and decreased glutamate-glutamine (Glx) in the co-infected patients compared to healthy controls.

Keywords

abnormalities addict adults advanced affecting albeit among analyzes approved approximately barrier basis blood board brain capable cerebral channel choline clinical coil combination common compromise concentrations condition conducting consent consisted consistent constitute contention controls coupled crossing currently decline decrease decreased define diffusion dimensional ding domain effort encode entire evidence examined experience extend findings fitting frequency frontal gives glutamate grant greater head health healthy hepatitis human hypothesis illustrate immunodeficiency in vivo increasing individual infected infection inflammation informed injury institute institutional laboratory linear link localization macrophages manual medial mental metabolic metabolite metabolites minutes model mono national nature neural neurology neuronal nominal normalized ongoing parietal participants pathology patients preliminary press previously processed protocol proton psychiatry quantified radiological receive reported resolved review rise routine sciences selective shim significantly singer slab sophisticated spectra spectroscopic spectroscopy spectrum statistically steps studies subject subjects suggests superior support supported supports tensor though understudied underwent untreated ventricles viruses vitro volume west white worse years