Meeting Banner
Abstract #3102

Optimal Thresholding of Tmax and Absolute Quantitative CBF Imaging in Acute Ischemic Stroke

Jeffry R. Alger1, Danny JJ Wang1, Sunny Q. Hao1, Michael G. Ho1, Noriko Salamon2, Jeffrey L. Saver1, David S. Liebeskind1

1Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA, United States; 2Radiological Sciences, Geffen School of Medicine at UCLA, Los Angeles, CA, United States

We sought to define the relationship between Tmax and absolute quantitative CBF in Dynamic Susceptibility Contrast studies of acute ischemic stroke. Doing so may provide insight into past successes and failures associated with using Tmax as a predictive parameter in addition to defining whether Tmax should continue to be used. Although Tmax is effective at detecting core ischemia, there does not appear to be a Tmax threshold that detects core ischemia with a high discriminatory power. Given that absolute CBF now be reliably obtained, thresholding of CBF images may provide a more reliable means of identifying core ischemic tissue volumes.

Keywords

absolute according accordingly acute addition agreement although arterial assigning automated automatically better blood bolus brain calculation cerebral clear clinical combination completely complication complications continue contrast contribute core curvature decomposition deconvolution deemed define defined delivery derived design detecting detects determined developed dimensional discriminating distal done drawing dynamic effective either encapsulated event experiencing expert failures flow fraction frequently function global greater head help hemorrhage identified identifying illustrates incorporated input inspection insufficient involved knowledge lesions likely limited location managed mask masks maximizes measured medicine month neurology noise occlusion operative optimal optimum partial past patient patients perfused poor post power presence problematic process produce progressively quantitative radiological read receive received related relationship relationships reliable reliably residue respect retrospectively salvageable scale school segment segmented selected singular slice software sought statistical stroke studies subject subjects subsequent substantial subtle successes succinctly suggests sunny threshold thresholded thresholding thresholds tissue traumatic unreliable various venous ventricular visual volume volumes whether zero